Testosterone can also be converted into the sex hormone estradiol (by the enzyme aromatase), ... (FSH) which regulate the number of Leydig cells and their secretion of testosterone.

To try to generate Leydig cells in vitro, Takaki Ishida, MD, from Kobe University, Japan, and colleagues used a two-step protocol employing clones of human induced pluripotent stem cells (iPSCs).

Less familiar is the male andropause, a hypothalamically mediated decrease in the production of testosterone by Leydig cells that is less complete and far more variable than the estrogen ...

Leydig cells are specialised interstitial cells within the testis responsible for the synthesis of testosterone, a critical hormone for male reproductive function and secondary sexual characteristics.

RESULTS: Significantly higher LH levels (median, 8.1 IU/L v 4.8 IU/L; P < .001) and generally lower testosterone levels (median, 12.5 nmol/L v 15.5 nmol/L; P = .13) were found in the CIS group. The ...

Orphagen Pharmaceuticals Presents Preclinical Efficacy Data at AACR 2022 on OR-449, a First-in-Class Steroidogenic Factor 1 Inhibitor, for the Treatment of Leydig Cell Tumors April 08, 2022 01:00 ...

This study will recruit 84 women. Everyone taking part will have a course of aromatase inhibitor tablets. The type of aromatase inhibitor you take will depend on what your cancer specialist recommends ...

This stops oestrogen stimulating the breast cancer cells to divide and grow. But sadly it does not help everyone. In this study, researchers want to find out why. They will look at samples from women ...