Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 18 (May 3, 2022), pp. 1-9 (9 pages) Regulation of hepatocyte proliferation and liver morphology is of ...

The endoplasmic reticulum (ER) is the portion of the cell responsible for manufacturing and folding proteins. Proteins are essential for a wide range of cellular functions—as enzymes, transporters, ...

Niigata, Japan - The research group of Professor Kamimura in Niigata University have reported the usefulness of a drug repositioning method based on the gene expression alteration in the chimeric mice ...

Hepatocyte nuclear factor 4α (HNF4α) is a master regulator of liver function and a tumor suppressor in hepatocellular carcinoma (HCC). In this study, we explore the reciprocal negative regulation of ...

Excessive alcohol consumption causes alcoholic liver disease, and about 20% of these cases progress to alcohol-associated steatohepatitis (ASH), which can lead to liver cirrhosis and liver failure.