Open Heart

Sex-disaggregated data in hypertrophic cardiomyopathy: a targeted literature review, meta-analysis and primary cohort study

Objective Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiomyopathy characterised by pathological left ...
BMJ Open

Income level and the risk of incident dementia among adults aged ≥50 with newly diagnosed type 2 diabetes: a population-based cohort study using the NHIS-Senior …

Introduction Type 2 diabetes mellitus (T2DM) is a well-established independent risk factor for dementia and is associated ...
ascopubs.org

Using Dose-Escalation and -Expansion Cohort Study as Pivotal Trial for Targeted Anticancer Drug Approval

BRCA1-Associated Protein 1 and Enhancer of Zeste Homolog 2: Pathway Interaction and Therapeutic Intervention in Breast Cancer, Mesothelioma, and Lymphoma Early-phase clinical trials (EPCTs) have been ...
Lupus Science & Medicine

Are RAS inhibitors necessary during intensive immunosuppression for lupus nephritis? Real-world evidence from the STAR cohort

Objective While guidelines advocate renin-angiotensin system inhibitors (RASi) for renoprotection in lupus nephritis (LN), ...
BMJ

Joint non-linear dose–response associations of device-measured physical activity and cardiorespiratory fitness with cardiovascular disease: a cohort and Mendelian ...

Objectives To characterise the non-linear joint dose–response relationship of accelerometer-measured moderate-to-vigorous physical activity (MVPA) and cardiorespiratory fitness (CRF, estimated as ...
Canadian Medical Association Journal

Association between sedative prescriptions after hospital discharge and falls and other adverse events in older adults: a population-based cohort study

Background:Whether sedative prescriptions after hospital admissions are associated with poor patient outcomes is unknown. We ...