NSAIDs work on a chemical level. They block the effects of special enzymes -- specifically Cox-1 and Cox-2 enzymes. These enzymes play a key role in making prostaglandins. By blocking the Cox ...

Despite advances in cancer treatment, many early-stage patients experience a recurrence when dormant cancer cells spread and ...

"Ibuprofen and other nonsteroidal anti-inflammatory drugs (NSAIDs) work by inhibiting cyclooxygenase enzymes, COX-1 and COX-2, which are used by the body to make signaling molecules called ...

When investigating NSAID inhibition of COX in vitro some important considerations are the source of the enzyme, the Michaelis constant (K m) of the endogenous substrate arachidonic acid ...

Cyclo-oygenase (COX) was the key enzyme that these drugs inhibited. Later, two forms of COX were identified, and it was possible to selectively inhibit each of them. For a general summary overview ...

Winn spent the last 10 of those years identifying the human gene responsible for coding the enzyme cyclooxygenase-2 (COX-2). They determined the mechanism by which the enzyme could be selectively ...

Their findings suggest potential interplay between cyclooxygenase enzyme, or COX, and indoleamine dioxygenases, or IDOs, during inflammation.