Despite advances in cancer treatment, many early-stage patients experience a recurrence when dormant cancer cells spread and grow into metastatic tumors. Scientists have now identified how aspirin ...

NSAIDs work on a chemical level. They block the effects of special enzymes -- specifically Cox-1 and Cox-2 enzymes. These enzymes play a key role in making prostaglandins. By blocking the Cox ...

When investigating NSAID inhibition of COX in vitro some important considerations are the source of the enzyme, the Michaelis constant (K m) of the endogenous substrate arachidonic acid ...

Cyclo-oygenase (COX) was the key enzyme that these drugs inhibited. Later, two forms of COX were identified, and it was possible to selectively inhibit each of them. For a general summary overview ...

Like the rooster's crow at sunrise, COX-2 serves as part of the body's alarm clock for infection or injury, alerting it to systemic changes and helping it prepare to respond. Infectious diseases ...

Parecoxib sodium has no inhibitory activity on either COX-1 or COX-2; all enzyme inhibitory effects are due to the activity of valdecoxib. It is the first injectable prodrug of a COX-2-specific ...

Their findings suggest potential interplay between cyclooxygenase enzyme, or COX, and indoleamine dioxygenases, or IDOs, during inflammation.