With smart DMPK strategies, cross-domain collaboration, and strong CDMO support, companies are pushing past the challenges of ...

Bile acids are essential to digestion, by acting like a kind of detergent that breaks up fat molecules. Fat doesn't dissolve in water, but our digestive system is full of water, so the fat we consume ...

Synthesized in the liver, bile acids play diverse roles in digestion and metabolism. However, when their processes are disrupted, disease can occur. Scientists seek advanced technologies to better ...

Primary bile acids are synthesized from cholesterol in the liver, which is transformed to cholic acid (CA) through the classical pathway and chenodeoxycholic acid (CDCA) as an alternative pathway.

This article highlights the ZenoTOF 8600 system's ability to detect, measure, and structurally describe bile acid levels in human plasma. Bile acid analysis in human samples has grown increasingly ...

Metabolites—small molecules within cells, biofluids, tissues or organisms—play an integral role in various diseases, and ...

A new study led by researchers at Baylor College of Medicine and published in the Proceedings of the National Academy of Sciences reveals that human noroviruses, the leading viral cause of foodborne ...

Scientists have discovered a new role for bile acids: they curb appetite by entering the brain. Their findings provide new insights into the signals and mechanisms by which satiety is controlled and ...

Immunotherapy is a modern approach to cancer treatment that uses a patient's own immune system to help fight tumors. It has made an incredible impact on treating cancers in many different organ ...