P-glycoprotein (Pgp) overexpression is a well-recognized factor in resistance to chemotherapy. Doxorubicin flow cytometry is used to monitor Pgp function in haematological specimens and biopsies from ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 76, No. 7 (Jul., 1979), pp. 3343-3347 (5 pages) We have investigated the role of the carbohydrate moiety in the ...

Thanks to a decadelong synthetic push, chemists finally have access to a homogeneous version of the blood-cell-producing glycoprotein erythropoietin (EPO). The product carries carbohydrates at the ...

Multidrug resistance (MDR) is a major obstacle in cancer therapy. It results from different mechanisms; among them is P-glycoprotein (P-gp)-mediated drug efflux out of cells. The mechanism of action ...