Lead Discovery Center GmbH has described 3-substituted 1H-pyrrolo[2,3-b]-pyridines acting as G protein-coupled receptor kinase 5 (GRK5) inhibitors reported to be useful for the treatment of cancer, ...
The human heart works under high demand, constantly pumping oxygen-rich blood through the body. When faced with disease, however, fulfilling this demand can become increasingly difficult and harmful.
This diagram illustrates the two different responses triggered by PAR1. PAR1 can trigger inflammation when activated by thrombin (left) or protection when activated by APC (right). GRK5 and ...
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