Hepatitis C virus (HCV) infections are a global health problem, with an estimated 70 million chronic infections worldwide, which can lead to hepatocellular carcinoma and cirrhosis of the liver. To ...

Parasitic infections pose challenges to creating effective therapies because these microorganisms are eukaryotic, like the humans and animals that they infect. Additionally, species like Toxoplasma ...

Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), remains a major global health challenge due to its complex host–pathogen interactions and the ...

Jonathan Kotula: We think there needs to be a systems-level approach to deal with complex diseases such as cancer. A lot of what has been done so far are reductionist approaches—one small molecule for ...

Autoantibodies against interleukin-12 (anti–interleukin-12) are often identified in patients with thymoma, but opportunistic infections develop in only some of these patients. Interleukin-12 (with ...