Endotoxin refers to a component of the outer cell membrane of Gram-negative bacteria called lipopolysaccharide (LPS). LPS is the biologically active portion of naturally occurring endotoxin complexes.

The presence of harmful bacteria in parenteral drugs or implantable devices can cause inflammatory responses such as fever and, in some cases, may even be fatal. As a result, robust bacterial ...

Novel Approach to Achieving Consistent Results with the Limulus Amebocyte Lysate Test The standard tool for screening endotoxins—highly toxic, heat-stable lipopolysaccharides that constitute the outer ...

With the introduction of pioneering technology for bacterial endotoxins testing (BET), it is critical to demonstrate equivalency across platforms. The Sievers Eclipse Ratio Verification Test was ...

Horseshoe crabs are harvested by the biomedical industry in order to create Limulus amebocyte lysate to test medical devices and pharmaceutical drugs for endotoxins. Most previous studies on the ...

A handful of scientists based in a nondescript West Ashley lab have played an integral role in making sure millions of COVID-19 vaccines are safe and bacteria-free. Tucked off Wappoo Road sits Charles ...

On a moonlit spring night on Cape Cod, female horseshoe crabs reenact a ritual that has persisted for over 450 million years. Within half an hour each female has laid several clutches of 4,000 eggs ...

New standards may help push more drugmakers to use a synthetic product for critical drug safety testing, instead of one made from horseshoe crab blood that has long drawn criticism. The U.S.

Your life may depend on horseshoe crabs. The distant relatives of spiders have trolled the seafloor for more than 300 million years. But 25 years ago, they figured in a key discovery of marine biology ...