Medscape

Omit Perioperative Chemotherapy in Mismatch Repair Deficient Gastric Cancer

Patients with mismatch repair deficient gastric cancer demonstrated better median overall survival when skipping perioperative chemotherapy, according to a preprint study. Median overall survival is ...
ascopubs.org

Randomized phase III trial in MMR deficient (MMRd) endometrial cancer (EC) patients comparing chemotherapy (CT) alone versus dostarlimab in first line advanced/metastatic ...

A randomized phase II study comparing single-agent olaparib, single-agent cediranib, and the combinations of cediranib/olaparib, olaparib/durvalumab (MEDI4736), cediranib/durvalumab (MEDI4736), and ...
ascopubs.org

Pre-transplant molecular minimal residual disease (MMRD) is associated with inferior outcomes in patients with acute myeloid leukemia undergoing allogeneic stem cell ...

Grade III-IV cytokine release syndrome is associated with inferior survival in patients undergoing haploidentical donor stem cell transplants. This is an ASCO Meeting Abstract from the 2020 ASCO ...
News Medical

Subclonal neoantigens present a key roadblock in MMRd tumor immunotherapy success

In a recent study published in Nature Genetics, researchers evaluated sensitivity to immune checkpoint blockade (ICB) therapy in autochthonous mouse models of DNA mismatch repair (MMR) deficiency ...