Week 17 is in the books for the NFL, and while some teams helped their playoff hopes, two divisions will come down to the final game in Week 18 after key losses.

Weeks 17 and 18 in NFL are all about scenarios. To name a few, there are teams that are win-and-in for a division title or playoff berth. Others will find motivation or discouragement in the result of an earlier game or some flickering numbers on the scoreboard.

The most important game of the weekend might actually occur in Las Vegas in a game that could have massive ramifications for the 2026 draft.

With San Francisco battling for positioning among three NFC West teams in the playoffs, McCaffrey was his do-it-all self Sunday night, rushing 23 times for 140 yards and a touchdown and catching another four passes for 41 yards against the Bears.

Derrick Henry's monster game against the Packers and a nightmarish Steelers loss headline the winners and losers from Week 17

What line moves can we predict this week? Let's take a look at the Week 17 lookahead lines at DraftKings and then share our best bets to lock in early.