Various approaches to such protein redesign have drawbacks. Traditional methods include time-consuming trial and error efforts, and many models in the emerging field ...
Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, No. 23 (June 8, 2021), pp. 1-9 (9 pages) Although it has long been proposed that membrane proteins may ...
In a recent study published in Molecular Systems Biology, researchers demonstrated that advances in modeling protein-ligand interactions using machine learning-based approaches are needed to exploit ...
Google DeepMind's groundbreaking new AI predicts not only the structure of proteins, ligands, DNA, RNA and "all of life's molecules," but how they'll interact. It promises a radical, revolutionary ...
In drug discovery, virtual screening is a fast and cost-effective way of narrowing down vast chemical libraries to identify the most promising hits, reducing synthesis and testing requirements while ...
GPCRs (G-protein-coupled receptors) represent the largest family of membrane receptors currently targeted by approved drugs. It is estimated that approximately 700 approved drugs target GPCRs ...
UCLA scientists have characterized the structure and function of a key survival protein in breast cancer cells that helps ...
The ability to alter proteins to refine control over binding affinity and specificity can create tailored therapeutics with reduced side effects, highly sensitive diagnostic tools, efficient ...
In biology, the binding of cellular proteins to molecules called ligands produces myriad functions essential for life, ...
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