The results of a new study using mice and heart muscle cells from rabbits have provided a potential molecular explanation for the abnormally rapid heartbeats known as ventricular tachyarrhythmias (VTs ...

Many damage-sensing neurons express tetrodotoxin (TTX)-resistant voltage-gated sodium channels. Here we examined the role of the sensory-neuron-specific (SNS) TTX-resistant sodium channel α subunit in ...

The BACE protease (β-site APP cleaving enzyme) is elevated in the brains of people with Alzheimer disease and takes at least part of the blame for amyloid overload because of its role in the ...

Approximately 2% of patients with irritable bowel syndrome (IBS) have a mutation of the SCN5A gene that disrupts sodium channel function, according to a genotype analysis published online March 10 in ...

This is a preview. Log in through your library . Abstract High resistance epithelia express on their apical side an amiloride-sensitive sodium channel that controls sodium reabsorption. A cDNA was ...

Hyperactive channels were generally associated with seizure onset in the first week of life. More impaired channel function was more common when the age of seizure onset was older. In fact, almost all ...

Blood may seem like a simple fluid, but its chemistry is complex. When too much potassium, for instance, accumulates in the bloodstream, patients may experience deadly irregular heart rhythms.

Thomas Kleyman, MD, professor of medicine and chief of the renal-electrolyte division at the University of Pittsburgh Medical Center, is a senior author of the study. Sodium channels found outside the ...

Scientists now have a better picture of how voltage-gated sodium (Na v) channels interact with certain animal toxins, thanks to structures solved with cryo-electron microscopy. These channels are ...

Electrical recordings from mouse neurons revealed differences in how a leading autism gene changes brain signaling before and after birth. Here scientists use pipettes (bright wedges) to record from ...

The results of a study, using mice and heart muscle cells from rabbits, by researchers from Georg-August-University Göttingen, Germany, have provided a potential molecular explanation for the ...