The alternative text for this image may have been generated using AI. We then wished to determine the nature of the mtDNA defect within the individual neurons in the substantia nigra that may account ...

Parkinson's Disease is the second most common neurodegenerative disorder. The focus of the disease is the progressive degeneration of dopamine-producing nerve cells in a certain region of the midbrain ...

Parkinson’s disease is a devastating condition whereby neurons in a specific region of the brain that controls movement lose functionality or die. This brain region is known as the substantia nigra — ...

Please provide your email address to receive an email when new articles are posted on . There is a need to look past dopaminergic therapy and target inflammation for disease modification. Chronic ...

About The Study: In this cross-sectional study of contact sports athletes with chronic traumatic encephalopathy (CTE), years of contact sports participation were associated with substantia nigra tau ...

Iron content is increased in the substantia nigra of persons with Parkinson’s disease and may contribute to the pathophysiology of the disorder. Early research suggests that the iron chelator ...

Parkinson's disease (PD) is an age-related, progressive neurodegenerative disorder. The hallmark of PD pathogenesis is the Lewy bodies (LBs) that accumulate in neurons in the substantia nigra region ...

The death of dopaminergic neurons in the substantia nigra is the defining feature of Parkinson’s disease, but not all neurons in the region suffer this fate. Why do some wither while others survive ...

The subtype of brain cells that die in Parkinson’s disease has been discovered using a new technique that can identify which genes are active in individual cells. We have known for decades that ...

Recently our film club has been watching the comedies of Jacques Tati, to my mind one of the great comic artists of the last century, right up there with Chaplin and Keaton. Running all through his ...