“If we want to address BBB dysfunction, we have to have a good human BBB model,” said Ziyuan Guo, a neurobiologist and stem cell scientist at Cincinnati Children's Hospital Medical Center. “The whole ...

Major advance promises to accelerate the understanding and improved treatment of a wide range of brain disorders, including stroke, cerebral vascular disorders, brain cancer, Alzheimer's disease, ...

The blood-brain barrier, a protective cell layer guarding the brain, blocks foreign bodies but also hinders drug delivery, complicating treatment of neurological disorders.Scientists have now devised ...

Focused ultrasound is just one strategy researchers are using to get drugs into the brain. This article first appeared in The Checkup, MIT Technology Review's weekly biotech newsletter. To receive it ...

In a recent primer paper published in the journal Current Biology, researchers elucidated the structure and function of the blood-brain barrier (BBB). It highlights the BBB as a complex, dynamic ...

Daiza Gordon watched her two younger brothers die when they were adolescents. They had Hunter syndrome, a rare, incurable disease — predominantly affecting boys — in which a gene for an important ...

Use of MRI-guided focused ultrasound with standard chemotherapy is safe and may improve outcomes for people with glioblastoma ...

Researchers at the Icahn School of Medicine at Mount Sinai say they have developed a lipid nanoparticle system capable of delivering messenger RNA (mRNA) to the brain via intravenous injection, a ...

CANDID-CNS™ is the new state-of-the-art AI model for BBB penetration: it achieves 87% AUPRC on bRo5 small molecules compared to 56% by Pfizer’s ...

By Vijay Kumar Malesu Scientists trace alcohol’s impact from the gut to the brain, uncovering microbial changes that weaken ...

Leakiness in the brain could explain the memory and concentration problems linked to long COVID. In patients with brain fog, MRI scans revealed signs of damaged blood vessels in their brains, ...