The firm will share updated data and new analyses from its Phase III trial with the agency, which issued a complete response ...

Saol Therapeutics, a privately held clinical-stage pharmaceutical company, today announced that the company has been granted ...

Saol Therapeutics received a complete response letter for its pyruvate dehydrogenase complex deficiency treatment a week ...

The FDA declined to approve a targeted treatment for PDCD – sodium dichloroacetate (DCA) – in September 2025 despite encouraging clinical evidence and the voices of PDCD families reinforcing the ...

Pyruvate dictates redox balance and cell size, establishing metabolism as a dominant regulator of cellular fitness, unveiling new strategies to modulate cancer, regeneration, and diabetes.

This is a preview. Log in through your library . Abstract The requirements for reactivation (dephosphorylation) of the pea (Pisum sativum L.) leaf mitochondrial pyruvate dehydrogenase complex (PDC) ...

Lung cancer, notorious for its high mortality rates, is a leading cause of cancer-related deaths globally, with metastasis being the primary contributor to poor patient outcomes. A critical factor in ...

Indications: Pyruvate dehydrogenase complex deficiency, typically associated with post-prandial lactic acidemia with a normal lactate/pyruvate ratio, can be assayed in freshly isolated blood ...

The pyruvate dehydrogenase complex consists of many different enzymes (marked in different colours). Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to ...