Purpose: A summary of the basic science underlying the current controversies regarding cyclooxygenase-2 (COX-2)-selective nonsteroidal antiinflammatory drugs (NSAIDs), including data on their ...

Celebrex (celecoxib) is a selective NSAID. It differs from non-selective NSAIDs because it targets the COX-2 enzyme, ...

Basically, they increase the pain you feel. NSAIDs work on a chemical level. They block the effects of special enzymes -- specifically Cox-1 and Cox-2 enzymes. These enzymes play a key role in ...

Over-the-counter NSAIDs inhibit both COX-1 and COX-2, but some, like aspirin and Aleve, are more selective for COX-1. Advil is considered non-selective. Examples of prescription NSAIDs that are ...

Clinical trials of several COX-2 selective and nonselective NSAIDs of up to 3 years duration have shown an increased risk of serious cardiovascular thrombotic events, including myocardial ...

NSAIDs are the principal agents used for managing pain in patients with chronically painful diseases, such as osteoarthritis. However, the withdrawal of the selective cyclo-oxygenase 2 (COX2 ...

NSAID research changed radically with the discovery that COX existed in two isoforms: the constitutively expressed COX-1 and an inducible COX-2 isoform 6. Analysis of the distribution of these ...

Clinical trials of several COX-2 selective and nonselective NSAIDs of up to 3 years duration have shown an increased risk of serious cardiovascular thrombotic events, including myocardial ...

[77] Intuitively, the combination of a COX-2-selective NSAID plus a proton pump inhibitor (PPI) should provide effective analgesia and further decrease the risk of upper-GI events compared to a ...