A new study published in Cell provides a remarkably detailed characterization of gut epithelial enterochromaffin cells (ECs), showing that they are able to sense luminal metabolites, irritants and ...

Enterochromaffin cells (blue) in finger-like projections within the gut villi (outlined in red) detect noxious chemicals. Photo by Holly Ingraham/David Julius labs. Specialized cells in the gut sense ...

They have discovered that enterochromaffin cells have receptors for sensing dietary irritants, stress hormones and bacterial byproducts. When exposed to these substances, the cells pump out ...

Moreover, the enterochromaffin cells likely mediate a selective response to SEA. This Tac1+-Hrt3a+-enterochromaffin circuit forms the gut-brain pathway that mediates defensive nausea, ...

Gut enterochromaffin cells regulate gut and bone homeostasis via serotonin production. A recent report suggested that gut microbes regulate serotonin levels, but the underlying molecular ...

Preliminary research shows that enterochromaffin cells don’t sense the presence of toxins directly. The process likely involves complex immune responses of damaged cells in the intestine.

The gut-brain axis: spatial relationship between spinal afferent nerves and 5-HT-containing enterochromaffin cells in mucosa of mouse colon.

A rare cell type in the gut, the enterochromaffin (EC) cell, drove both gut discomfort and anxiety symptoms in animal models of gastrointestinal pain. Furthermore, the cells reacted differently in ...

However, when Zeng and her team profiled the metabolites in the gut of neonatal mice, they found that the neonatal intestine had an unexpectedly high amount of the neurotransmitter serotonin. But the ...

Background: Gastric carcinoid tumors, previously known as neuroendocrine neoplasms, are derived from enterochromaffin cells and show an increasing incidence globally. Neuroendocrine tumors often ...

David Julius et al. Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways. Cell , June 2017 DOI: 10.1016/j.cell.2017.05.034 Cite This Page : ...