Drugs that bind to and activate the receptors for the hormones GLP-1 and GIP are effective in the treatment of obesity and ...

The SCAN enzyme employs this mechanism, selectively nitrosylating target proteins such as the insulin receptor and its ... drawing parallels to other signal transduction processes like ...

Ronald Kahn, MD, is an internationally recognized expert in diabetes and obesity research, as well as a preeminent investigator in the area of insulin signal transduction and mechanisms ... our ...

Using retroviral transduction ... We identified key pathways that contribute to this resistance, including: Androgen receptor (AR) activation IGF-I/PI3K/Akt/mTOR signaling Rb inactivation LIM domain ...

Besides nuclear peroxisome proliferator-activated receptors ... of insulin [9]. Moreover, FFAs lead directly to reduction in the uptake and phosphorylation of glucose and to a reduced glycogen ...

Certain nutrients have been shown to support healthy glucose metabolism by improving insulin sensitivity and reducing ... sugar levels after eating glucose metabolism and insulin receptor signal ...

Focal cortical dysplasia (FCD) type 2 is a congenital malformation of the cerebral cortex that is often associated with difficult-to-treat epilepsy. In the affected areas, nerve cells and their layer ...

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs ... When a GLP-1 RA is prescribed along with insulin, it can increase the odds of hypoglycemia. Because GLP-1 RAs slow digestion, they may ...

Individuals with diabetes are susceptible to cardiac dysfunction and heart failure, potentially resulting in mortality. Metabolic disorders frequently occur in patients with diabetes, and diabetes ...

We previously reported a novel adaptor protein, ARAP, required for T cell receptor signaling and integrin-mediated adhesion. The present study investigates further the role of ARAP in T cell biology ...