Since its discovery in 1984 by Svetlana Mosjov, GLP-1 and its analogs (such as semaglutide, liraglutide, and dulaglutide) have rapidly become cornerstone treatments for type 2 diabetes mellitus ...

This shift away from fact-driven rhetoric coincides with rising partisan polarization, growing income inequality, and decreasing legislative productivity. Essentially, Congress may be getting less ...

This study presents a valuable finding on the role of cholesterol-binding site on GLP-1 receptors and functionally characterizes the impact of this mutation on receptor behavior in the membrane and ...

The new material combines the functions of hydrogen's antioxidant and anti-inflammatory properties and magnesium's promotion of angiogenesis and macrophage polarization, among others. They work ...

Nature 545: 495-499. 47. Liu N, Zhang J, Yin M, et al. (2021): Inhibition of xCT suppresses the efficacy of anti-PD-1/L1 melanoma treatment through exosomal PD-L1-induced macrophage M2 polarization.

This study sought to determine whether the SOCS3/JAK/STAT3 signaling pathway, which controls macrophage polarization, contributes to the cardiotoxicity caused by PD-1/PD-L1 inhibitors. The PD-1/PD-L1 ...

The study involved a comprehensive dataset constructed from 35 carefully selected academic papers, out of an initial 128, focusing on 13 features related to macrophage polarization. After ...

Similarly, animal studies have shown that liraglutide helps alleviate pain from this condition. In addition to weight loss, which eases joint stress and improves mobility, GLP-1 analogs have anti ...

Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada (C.S., K.J.R). Centre for Infection, Immunity ...

In 2008, a group of published studies claimed that a treatment called Gc protein-derived macrophage-activating factor (GcMAF) had wiped out breast, colorectal, and prostate cancers. The studies ...

Liraglutide injection is a GLP-1 receptor agonist used to improve glycemic control in adults and pediatric patients with type 2 diabetes More than 38 million people live with diabetes in the U.S.1 ...