Also at the BetMGM, in tickets, this matchup is the most-bet game of the entire opening-week slate and the point total is the second-most-bet in Overs. Let's take a closer look at the odds at BetMGM ...

Best NFL Week 1 against the spread bets Kansas City Chiefs (-2.5) vs. Los Angeles Chargers (-110 at Fanatics) San Francisco 49ers (-1.5) vs. Seattle Seahawks (-108 at DraftKings) ...

2025 NFL futures: Aggregate point spreads provide another component for analyzing teams, odds SportsLine has crafted a season-long NFL spread formula that can serve as a data point for team rankings.