AbstractThere is an unmet need to develop novel treatment options for patients with metastatic castration-resistant prostate cancer (mCRPC). Patients often develop resistance to next-generation ...

AbstractDysregulation of Hippo signaling, especially the downstream effector YAP, is a critical driver of hepatocellular carcinoma (HCC). Therefore, identifying therapeutic targets to block Hippo ...

AbstractBackground:. Cancer incidence data collected by cancer registries in the United States and Canada are submitted to the North American Association of Central Cancer Registries, which publishes ...

Once considered a high-value target, CD47 attracted billions in industry investment. Safety concerns, modest efficacy, and trial challenges, however, ultimately led Gilead, Pfizer, and others to scrap ...

Actinium-225, a potent α-emitting radioisotope that’s shown promise in treatment for cancer, is in high demand but in limited supply. As clinical trials using actinium-based therapies surge, major ...

AbstractPurpose:. Tumor immune cell infiltration patterns in the tumor microenvironment serve as prognostic biomarkers in metastatic colorectal cancer. This study analyzed the spatially resolved tumor ...

Treatment with China–based Sichuan Kelun-Biotech Biopharmaceutical’s TROP2-targeting antibody–drug conjugate (ADC) sacituzumab tirumotecan significantly improved overall survival (OS) in two cohorts ...

A study shows that platelets can carry tumor DNA in their cytoplasm, sometimes in higher amounts than in plasma. Adding this platelet-derived DNA to liquid biopsy workflows could improve cancer ...

SpringWorks Therapeutics announced today that its gamma secretase inhibitor nirogacestat (Ogsiveo) was approved by the European Commission for the treatment of adults with desmoid tumors, which are ...

AbstractIdentifying functionally important cell states and structure within heterogeneous tumors remains a significant biological and computational challenge. Current clustering- or trajectory-based ...

AbstractCirculating tumor cells (CTCs) are cells shed from tumors into the bloodstream, providing a unique source of information on tumor biology. CTCs can be collected through liquid biopsy, offering ...

Abstract. The effectiveness of T cell–based immunotherapy depends on durable T-cell responses that can efficiently eliminate tumor cells. NKG7 was discovered three decades ago as a protein associated ...