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Purpose: A summary of the basic science underlying the current controversies regarding cyclooxygenase-2 (COX-2)-selective nonsteroidal antiinflammatory drugs (NSAIDs), including data on their ...

NSAIDs (non-steroidal anti-inflammatory drugs) are a class of medications commonly used to reduce pain, inflammation, and fever. They work by blocking enzymes (COX-1 and COX-2) that produce ...

An important factor in referring to NSAIDs as 'COX-2 selective inhibitors' or 'COX nonselective inhibitors' is that 'selective' inhibition by NSAIDs is referred to at the level of the COX proteins ...

14 One support of this “cyclooxygenase theory” is the demonstration that pretreatment with leukotriene-receptor antagonists can block NSAID-induced urticaria ... agent such as thienopyridines. 7 ...

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Medically reviewed by David Ozeri, MD Prescription anti-inflammatory medications are used to reduce pain, inflammation, and ...

Interestingly, MTX-induced cyclooxygenase-2 (COX-2) expression, intestinal permeability and inflammation were attenuated after MgIG administration. In addition, MgIG (9 and 18 mg/kg) reduced ...

To clarify that point, fibroblasts migration was induced by lipopolysaccharide (LPS) in NIH3T3 cells with or without selective tools [NS-398, a COX-2 inhibitor; DKK-1, an antagonist of the β-catenin ...

a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenases (COX) -1 and -2. Indomethacin was tested in both acute and chronic exposure models in mice at clinically relevant doses, ...