A new study published in Cell provides a remarkably detailed characterization of gut epithelial enterochromaffin cells (ECs), showing that they are able to sense luminal metabolites, irritants and ...

Enterochromaffin cells (blue) in finger-like projections within the gut villi (outlined in red) detect noxious chemicals. Photo by Holly Ingraham/David Julius labs. Specialized cells in the gut sense ...

They have discovered that enterochromaffin cells have receptors for sensing dietary irritants, stress hormones and bacterial byproducts. When exposed to these substances, the cells pump out ...

Gut enterochromaffin cells regulate gut and bone homeostasis via serotonin production. A recent report suggested that gut microbes regulate serotonin levels, but the underlying molecular ...

Moreover, the enterochromaffin cells likely mediate a selective response to SEA. This Tac1+-Hrt3a+-enterochromaffin circuit forms the gut-brain pathway that mediates defensive nausea, ...

The gut-brain axis: spatial relationship between spinal afferent nerves and 5-HT-containing enterochromaffin cells in mucosa of mouse colon.

The article ‘The gut-brain axis: spatial relationship between spinal afferent nerves and 5-HT-containing enterochromaffin cells in mucosa of mouse colon’ by Kelsi N. Dodds, Lee Travis, Melinda ...

A rare cell type in the gut, the enterochromaffin (EC) cell, drove both gut discomfort and anxiety symptoms in animal models of gastrointestinal pain. Furthermore, the cells reacted differently in ...

During in vitro differentiation, a significant number of cells may acquire an unwanted identity, resembling serotonin-producing enterochromaffin cells, which complicates their application in T1DM ...

Background: Gastric carcinoid tumors, previously known as neuroendocrine neoplasms, are derived from enterochromaffin cells and show an increasing incidence globally. Neuroendocrine tumors often ...

David Julius et al. Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways. Cell , June 2017 DOI: 10.1016/j.cell.2017.05.034 Cite This Page : ...