The tumor microenvironment (TME) is a complex and dynamic ecosystem crucial for cancer progression and therapeutic response. Tumors actively shape this ...

Isoliquiritigenin (ISL), a flavonoid derived from licorice root, has received widespread attention due to its multifaceted therapeutic effects. This study demonstrates that ISL mitigates ...

Conclusions NLRP6 promotes HCC progression by inhibiting macrophage infiltration and suppressing phagocytosis via the interaction between its PYD domain and E-Syt1’s SMP domain. Transfer of Nlrp6 −/− ...

Macrophages are the predominant immune cell type within the TME, exhibiting remarkable plasticity that enables them to adopt different phenotypes. This process, known as macrophage polarization, ...

The CX3CL1-CX3CR1 axis plays a critical role in promoting tumor cell proliferation, migration, and metastasis in PDAC. Targeted delivery of small interfering RNA (siRNA) against CX3CR1 through M1 ...

For adults with obesity and migraine, liraglutide reduces migraine burden, with reductions in mean monthly headache days, ...