Further studies revealed that ENO2-mediated HNSCC metastasis was associated with M2 macrophage polarization. ENO2 regulated M2 macrophage polarization through its metabolite phosphoenolpyruvate (PEP).

ENO2 regulated M2 macrophage polarization through its metabolite phosphoenolpyruvate (PEP). PEP could increase histone H3 lysine 18 lactylation (H3K18la) levels by inhibiting the catalytic ...

Mechanistic studies showed that Lrrk2 promotes macrophage polarization toward the M1 phenotype by enhancing STAT1 phosphorylation in response to IFN-γ signaling.

This study elucidated the role of ENO2 in modulating macrophage polarization and contributing to HNSCC metastasis. It also revealed the mechanism by which ENO2-derived PEP regulates histone ...