ACE2 (angiotensin-converting enzyme 2) is a monocarboxypeptidase that cleaves Ang II (angiotensin II) among other substrates. ACE2 is present in the cell membrane of many organs, most abundantly in ...

An image of a mouse kidney glomerulus taken on a fluorescence microscope showing cell nuclei in blue, the PIEZO2 gene in magenta, and the renin gene in green. Each dot represents a single mRNA ...

Phase 1 data in healthy volunteers exceed expectations and support best-in-class potential, enabling Phase 2 advancement for both intended indications of PKU and CKD Dose-dependent urinary amino acid ...

To provide medical professionals (RN, MD, Pharmacist) with the knowledge and understanding for decision making for the effective utilization of Continuous Renal Replacement Therapy (CRRT) and to allow ...

Dr. Peirce invited Kuhn to co-lecture on Renal Replacement Therapy for second-year medical students. The session, held in Fall 2023, featured hands-on props including dialyzers, dialysis needles, ...

Receipt of female hormones appeared to lead to protective vasodilation in nephrons. Male hormone use appeared to induce subclinical kidney stress. A prospective observational study of transgender ...

ABSTRACT: Chronic Kidney Disease (CKD) poses a significant healthcare challenge in Saudi Arabia, necessitating a structured approach to management and treatment. Recent consensus guidelines in Saudi ...

A team developed a human iPS cell-derived kidney organoid-based proximal tubule-on-chip -- OPTECs-on-Chip -- that mimics in vivo renal physiology more closely than ever before. This model exhibits ...

Developing advanced drug screening tools is crucial for the advancement of personalized medicine and the creation of more effective treatments. One organ receiving particular attention in this area is ...

Gout is a type of inflammatory arthritis that causes flare-ups of joint swelling and pain. Kidney disease and gout commonly co-occur and may each contribute to the development of the other. Gout is a ...