The news that senior officials in the Trump administration discussed plans on Signal, a commercial messaging app, for an impending attack angered and bewildered men and women who have taken to the ...

The PI3K/AKT/mTOR (PAM) signaling pathway is a classical pathway that is aberrantly activated in cancer cells and promotes the tumorigenesis, metastasis, resistance to castration therapy, ...

State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200433, China Laboratory of Molecular Materials and Devices, Fudan ...

They are generally composed of combinatorial connections of individual signaling pathways. In these structures, nodes or hubs play a critical role for network topology and determine their emergent ...

The Notch signaling pathway regulates developmental cell-fate decisions and has recently also been linked to inflammatory diseases. Although therapies targeting Notch signaling in inflammation in ...

This action of Rspo1 is through activating G-protein coupled cAMP/PKA pathway, while independent of Wnt/β-catenin signaling. Our data reveal a novel Wnt-independent role of Rspo1, and a new upstream ...

The intracellular signaling molecule Dishevelled (Dvl) mediates canonical and non-canonical Wnt signaling via its PDZ domain. Different pathways diverge at this point by a mechanism that remains ...