Wnt signaling pathways play roles in many developmental processes such as, cell proliferation, differentiation, migration, and regulation of cell polarity. Disorders in Wnt/beta-catenin signaling ...

As a highly conserved cell-to-cell communication mechanism, the Wnt/β-catenin signaling pathway coordinates a wide spectrum of processes by activating the expression of Wnt target genes (1).

Mechanistically, DDX24 inhibits the VEGF pathway by promoting VEGFR2 mRNA degradation in nonbrain endothelial cells (ECs), while activating GPR124/RECK-mediated Wnt signaling in brain ECs. Spatial ...

Abstract Hyper-activation of the canonical Wnt signaling pathway drives small intestine and colon tumors. As the major Wnt pathway effector in healthy intestines, TCF7L2 is a suspected oncogene in ...

Glypican 3 and glypican 4 bind to the plasma membrane and regulate the Wnt, BMP, and FGF signaling pathways associated with bone growth. Polygenic Contributors to Human Height ...

Mitogen-activated protein kinase (MAPK) and Wnt signaling pathways are critical for melanocyte development and melanogenesis and could be novel therapeutic targets for modulating melanin synthesis ...

SOUTH SAN FRANCISCO, Calif., March 24, 2025 (GLOBE NEWSWIRE) -- Surrozen, Inc. (“Surrozen” or the “Company”) (Nasdaq: SRZN), a company pioneering targeted therapeutics that selectively activate the ...

Role of Wnt signaling in HCC pathogenesis The Wnt/β-catenin pathway is essential for HCC development. Its activation promotes hepatocyte proliferation, inhibits apoptosis, and enhances tumor cell ...

Research have confirmed that the Wnt/β-catenin signaling pathway is an important driving factor for the occurrence and development of osteosarcoma, and abnormal activation of this pathway can promote ...

We further demonstrated that DVL proteins promote ligand-independent FZD receptor endocytosis but do not affect Wnt-induced FZD5/8-specific endocytosis and degradation. Furthermore, we reevaluated the ...

Lgr5 + intestinal stem cells (ISCs) are crucial for the intestinal epithelium renewal and regeneration after injury. However, the mechanism underlying the interplay between Wnt and BMP signaling in ...