Texas A&M (8-7, 1-2 SEC) found themselves facing a 25-10 disadvantage after the first quarter and 37-17 at halftime.
Jerkaila Jordan scored 24 points, 18 in the second half, and Mississippi State held on for a 81-77 win over No. 10 Oklahoma.
The Texas A&M Aggies (13-2, 2-0 SEC) play the LSU Tigers (11-4, 0-2 SEC) in a clash of SEC teams at 8:30 PM ET on Saturday.