Accumulation of APP C-terminal fragments causes endolysosomal ...
Apr 27, 2024 · The authors convincingly show that the inhibition, or loss, of γ-secretase activity results in endolysosomal dysfunction, such as early endosome enlargement, changes in lysosomal calcium, …
Interactions between TTYH2 and APOE facilitate endosomal lipid …
Jul 11, 2025 · An interesting avenue for future research is to better characterize the interactions that ApoE undergoes as the endosome matures and fuses with the lysosome. Do other proteins take …
Endosomal Dysfunction Induced by Directly Overactivating Rab5 ...
Jan 13, 2021 · A strength of the paper is that the authors go on to use the new mouse model to explore different pathological consequences for increased Rab5a activation and endosome dysfunction on …
APP C-Terminal Fragments Stifle Calcium Flow from ER to Lysosomes
Apr 27, 2024 · These results indicate a delay in endosome-to-lysosome maturation, with lysosomes failing first. Calcium levels in lysosomes also fell by 30 percent in the 24 hours after DAPT. Bretou …
When SORL1 Dimerizes in Endosomes, Retromers Recycle APP Faster
Feb 2, 2023 · Indeed, they found that SORL1 dimers in the endosome existed almost entirely in complex with retromer. How might SORL1 dimerization influence the recycling and processing of APP? To …
Familial AD Mutations, β-CTF, Spell Trouble for Endosomes
Aug 17, 2019 · Panel of isogenic iPSC-derived neurons with familial AD mutations: a new research resource. Endosomes were enlarged, and β-CTF—not Aβ—was the cause. FAD mutations changed …
Going It Alone—APP, BACE1 Take Distinct Routes to Endosome
Aug 17, 2011 · Here, the group of Wim Annaert shows that APP and BACE1 are internalized in distinct endocytic routes to reach the early endosome compartment. The authors show that while APP is …
ApoE and Tweety Homolog 2—Proteins that Flock Together?
Jul 11, 2025 · The role of ApoE has been well-studied outside of the cell, but what happens after it’s let inside? Scientists led by Raimund Dutzler, University of Zurich, have identified Tweety homologue 2 …
ALS/FTD Genes Converge on Endolysosomal System, Stoking TDP-43 ...
Oct 18, 2022 · Still, mechanistic mysteries remain. “How impaired endosome maturation leads to the formation of TDP-43 inclusions in the cytoplasm and nuclear depletion, whatever comes first, are still …
Toward an AD CRISPR Therapy: Tweaking APP Terminus Cuts Plaque
Jun 27, 2024 · Researchers led by Subhojit Roy at the University of California, San Diego, used CRISPR gene editing to remove a six-residue motif that targets APP to the endosome, where β-secretase, …