Lipid-Based Nanoparticles for Drug/Gene Delivery: An Overview …
In this review, we introduce the main types of LNPs used in drug formulations such as liposomes, nanoemulsions, solid lipid nanoparticles, nanostructured lipid carriers, and lipid polymer hybrid …
Lipid-based nanoparticle - Wikipedia
Development of solid lipid nanoparticles is one of the emerging fields of lipid nanotechnology (for a review on lipid nanotechnology, see [16]) with several potential applications in drug delivery, …
Lipid nanoparticles: Composition, formulation, and application
Jun 12, 2025 · In this review, we first introduce the LNP components, highlighting their critical roles in encapsulation, stability, delivery efficiency, and tissue tropism. Next, we summarize …
Designing lipid nanoparticles using a transformer-based neural
Aug 15, 2025 · The effectiveness of an LNP is determined by its lipid components and their ratios; however, experimental optimization is laborious and does not explore the full design space.
A complete guide to understanding Lipid nanoparticles (LNP)
Nov 18, 2025 · Discover the power of Lipid Nanoparticles (LNP), including an introduction to LNPs composition, manufacturing methods, and their applications
More than a delivery system: the evolving role of lipid-based nanoparticles
Apr 2, 2025 · In this review, we focus on how our understanding of lipid structure and function in biological contexts can be used to design intrinsically functional and targeted nanocarriers.
Next-Generation Nanostructured Lipid Carriers: A Review of Latest ...
Dec 4, 2025 · Nanostructured lipid carriers (NLCs) are the latest advancement in formulations and more rational drug delivery systems, addressing several drawbacks associated with the use of …
A Deeper Look at Lipid Nanoparticles - beckman.com
The study and manipulation of small particles continue to drive advancements across multiple disciplines, highlighting their importance as an emerging technology. Here we focus on …
Lipid nanoparticle technology for therapeutic gene regulation …
Here we discuss the state-of-the-art LNP technology for hepatic gene therapy including formulation design parameters, production methods, preclinical development and clinical …
Lipid nanoparticles for mRNA delivery - Nature Reviews Materials
Aug 10, 2021 · In this Review, we discuss the design of lipid nanoparticles for mRNA delivery and examine physiological barriers and possible administration routes for lipid nanoparticle–mRNA …
Lipid-Based Nanoparticles for Drug/Gene Delivery: An Overview …
Aug 21, 2023 · In this review, we introduce the main types of LNPs used in drug formulations such as liposomes, nanoemulsions, solid lipid nanoparticles, nanostructured lipid carriers, and …
Exploring the landscape of Lipid Nanoparticles (LNPs
Dec 1, 2024 · Lipid nanoparticles (LNPs) have emerged as promising carriers for delivering therapeutic agents, including mRNA-based immunotherapies, in various biomedical …
A review of technological developments in lipid nanoparticle ...
To address this, lipid nanoparticle (LNP) technology has emerged as a promising delivery system for mRNA vaccines.
The untapped potential of mRNA–lipid nanoparticles - Nature
Sep 11, 2025 · In less than a decade, lipid nanoparticle (LNP) technology for RNA delivery has progressed from proof-of-concept to global-scale deployment. The approval of Onpattro in …
What are lipid-based nanoparticles? - Inside Therapeutics
Jun 10, 2025 · Lipid-based nanoparticles (LBNPs) are advanced delivery systems designed to transport therapeutic molecules with high precision and stability. This guide explains their …
Lipid Nanoparticles (LNPs) for Drug/Gene Delivery - Danaher Life …
Various methods are employed to produce lipid nanoparticles (LNPs) for mRNA delivery. High-pressure homogenization involves subjecting a mixture of lipids and an aqueous phase to high …
Looking Back, Moving Forward: Lipid Nanoparticles as a …
Introduction Lipid nanoparticles (LNPs) have garnered attention as a valuable tool in biomedical applications, with recent studies showing their potential in fighting several medical conditions. …
The 60-year evolution of lipid nanoparticles for nucleic acid
Jul 4, 2024 · The development of LNP technology for nucleic acid delivery is based on insights gained from basic studies on the physical properties and functional roles of lipids in …
mRNA Loaded Lipid Nanoparticles in Personalized Cancer …
Sep 5, 2025 · Against this backdrop, this review offers a critical appraisal of mRNA-loaded lipid nanoparticles as enabling vectors for cancer vaccination.
The impact of, and expectations for, lipid nanoparticle technology ...
Jun 1, 2024 · In this review, we describe our progress using a lipid library to engineer ionizable lipids and promote LNP technology from the viewpoints of safety, controlled biodistribution, …
The impact of, and expectations for, lipid nanoparticle technology ...
In this review, we describe our progress using a lipid library to engineer ionizable lipids and promote LNP technology from the viewpoints of safety, controlled biodistribution, and mRNA …
Lipid nanoparticles for delivery of RNA therapeutics: Current …
Lipid nanoparticles (LNPs) have been one of the most successful nano-delivery vehicles that enable efficient delivery of cytotoxic chemotherapy agents, antibiotics, and nucleic acid …
Engineered biodegradable polymeric nanoparticles injectable …
5 days ago · In the present study, an injectable system of ATR-loaded polymeric nanoparticles was synthesized through the spray drying technique using chitosan polymer extracted in …
Lipid nanoparticles (LNPs) for in vivo RNA delivery and their ...
In this review, we highlight the fundamental aspects of LNPs and their uses in the development of novel RNA therapeutics. Recent advances in LNP-based therapeutics and preclinical/clinical …