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jove.com
Video: Retroviral Transduction of Bone Marrow Progenitor Cells to Generate T-cell Receptor Retrogenic Mice
9.9K Views. Baylor College of Medicine. The goal of this procedure is to generate retrogenic mice to determine the in vivo function of multiple t-cell receptors. This is accomplished by utilizing a retroviral construct that encodes the alpha and beta chains of the t-cell receptor, linked by a 2A peptide consensus motif. This method can actually ...
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